PROGRAMME
SCIENTIFIC PROGRAMME
—
SCIENTIFIC PROGRAMME
WEDNESDAY
14 / 11
THURSDAY
15 / 11
FRIDAY
16 / 11
SATURDAY
17 / 11
This teaching course covers both basic and advanced magnetic resonance imaging in vascular cognitive impairment (VCI). The spotlight will be on cerebral small vessel disease (SVD), the most common cause of VCI. The course will provide an overview of concepts and methods and starting points for exploration of emerging techniques. We will also point out major pitfalls in SVD neuroimaging.
We will first explore the classical lesion spectrum of SVD, both for ischemic and hemorrhagic lesions (presented by Prof. de Leeuw). Recently it has been discovered that these lesions are highly dynamic. They appear and grow but can also shrink and even disappear. The second part is an in-depth look into diffusion imaging, a major technique to study microstructural alterations of white matter in SVD (presented by Dr. Duering). We will cover basic diffusion tensor imaging as well as advanced diffusion modelling and structural connectomics. The third part is on emerging techniques offering pathomechanistic insights (presented by Dr. Doubal), i.e. measurement of blood-brain-barrier permeability by dynamic contrast enhanced imaging and assessment of cerebrovascular reactivity.
9:00 - 10:30 AM
TEACHING SESSION
Neuroimaging in VCI
SPEAKERS
Frank-Erik de Leeuw (Netherlands), Fergus Doubal (United Kingdom) and Marco Duering (Germany)
Grand Hall
10:30 - 11:00 AM
COFFEE BREAK
Pre-Function Hall
Up to a third of all dementia cases can be attributed to modifiable risk factors. You can manage these risk factors using both pharmacological and non-pharmacological approaches. In this interactive teaching session you will learn about the latest insights from research on cardiovascular risk management, novel pharmacological options, and lifestyle strategies. What are the key factors of success? Also, we will be exploring whether the e-health field could play a role. Finally, we will discuss practical challenges and tips and would love to hear your experiences during the discussion.
11:00 - 12:30 PM
TEACHING SESSION
Clinical Management of VCI: Pharmacological and Lifestyle Approaches
SPEAKERS
Majon Muller (Netherlands) and Astrid Hooghiemstra (Netherlands)
Grand Hall
12:30 - 1:30 PM
LUNCH
Pre-Function Hall
12:30 - 1:30 PM
GLOBAL COLLABORATIVE PLATFORM
[P-17] Who Should Undergo a Comprehensive Cognitive Assessment After a Stroke? The GRECogVAS Cognitive Risk Score.
PRESENTING AUTHOR
Olivier Godefroy (France)
[P-36] Profile and Risk Factors of Post-Stroke Cognitive Impairment in Diverse Ethno-Regional Groups: An Individual Participant Data Meta-Analysis from the STROKOG Consortium
PRESENTING AUTHOR
Jessica Lo (Australia)
[P-109] Meta-Analyses of Strategic Lesion Locations for Vascular Cognitive Impairment Using Lesion-Symptom Mapping – The Meta VCI Map Consortium
PRESENTING AUTHOR
Nick Weaver (Netherlands)
[P-149] Factors Associated with Mixed Dementia: Need for Clinical Criteria and Neuroimaging
PRESENTING AUTHOR
Alberto Mimenza Alvarado (Mexico) and Sara Aguilar Navarro (Mexico)
Grand Hall
The VasCog 2018 neuropsychological testing session will focus on the interpretation of neuropsychological test data within the context of hypothetical constructs as related to brain and cognition, and; how to use neurocognitive constructs to help define specific phenotypic profiles associated with dysexecutive disorders and amnesia. The clinical application of these hypothetical constructs will be used to illustrate phenotypic profiles that typify Alzheimer’s disease, vascular dementia associated subcortical white alterations, mild cognitive impairment subtypes. Additional topics to be discussed are the integration of classic neuropsychological assessment paradigms with new digital technology, and how new technology may be used to better understand or disambiguate brain – behavior relationships.
1:30 - 3:00 PM
TEACHING SESSION
Neuropsychology
SPEAKER
David Libon (USA)
Grand Hall
3:00 - 3:30 PM
COFFEE BREAK
Pre-Function Hall
Recent advances in in vivo optical microscopic imaging and single-cell biology has dramatically enhanced our understanding of mechanisms underlying the regulation of the blood-brain-barrier and neurovascular coupling. This teaching session intends to give an overview of basic research in neurovascular biology and introduce an array of basic science techniques including multiphoton microscopy, vascular mural cell transcriptomic studies to young researchers, with illustrations by experimental protocols and highlights from the speaker’s lab.
3:30 - 5:00 PM
TEACHING SESSION
Basic Neurosciences
SPEAKER
Owen Ko (Hong Kong)
Grand Hall
5:15 - 7:30 PM
WELCOME RECEPTION
ClubONE on the PARK, Building 12W, Hong Kong Science Park
8:45 - 9:00 AM
OPENING CEREMONY
Grand Hall
9:00 - 9:30 AM
THEME
Potential Mechanisms in VCI
PLENARY SESSION
Control of Cerebral Blood Flow by Capillary Pericytes in Health and Disease
SPEAKER
David Attwell (United Kingdom)
Grand Hall
9:30 - 9:50 AM
THEME
Potential Mechanisms in VCI
SYMPOSIUM SESSION
Potential Mechanisms of Stroke in CADASIL
SPEAKER
Toshiki Mizuno (Japan)
Grand Hall
9:50 - 10:10 AM
THEME
Potential Mechanisms in VCI
SYMPOSIUM SESSION
Intramural Periarterial Drainage Pathways and the pathogenesis of VCI
SPEAKER
Roxana Carare (United Kingdom)
Grand Hall
10:10 - 10:20 AM
THEME
Potential Mechanisms in VCI
SELECTED ORAL PRESENTATION
[P-223] Left Atrial Remodeling Without Known Atrial Fibrillation Increases Risk of Stroke, Incident AF and Death
PRESENTING AUTHOR
Jodi Edwards (Canada)
Grand Hall
10:20 - 10:30 AM
THEME
Potential Mechanisms in VCI
SELECTED ORAL PRESENTATION
[P-119] Autonomic Dysfunction and Small Vessel Disease in Vascular and Neurodegenerative Dementias
PRESENTING AUTHOR
Yoshiki Hase (United Kingdom)
Grand Hall
10:30 - 11:00 AM
COFFEE BREAK
Pre-Function Hall
11:00 - 11:30 AM
THEME
Neuroimaging and Other Biomarkers in VCI
PLENARY SESSION
Neuroimaging and Other Biomarkers in VCI
SPEAKER
Eric Smith (Canada)
Grand Hall
11:30 - 11:50 AM
THEME
Neuroimaging and Other Biomarkers in VCI
SYMPOSIUM SESSION
Alzheimer’s Pathology Biomarkers in Subcortical Vascular Cognitive Impairment
SPEAKER
Sang Won Seo (Republic of Korea)
Grand Hall
11:50 - 12:10 PM
THEME
Neuroimaging and Other Biomarkers in VCI
SYMPOSIUM SESSION
Novel Marker of Vascular Cognitive Impairment
SPEAKER
Saima Hilal (Netherlands)
Grand Hall
12:10 - 12:20 PM
THEME
Neuroimaging and Other Biomarkers in VCI
SELECTED ORAL PRESENTATION
[P-130] Diffusion-Weighted Imaging Lesions Increase the Risk of Incident Dementia in Individuals with Cerebral Small Vessel Disease
PRESENTING AUTHOR
Kim Wiegertjes (Netherlands)
Grand Hall
12:20 - 12:30 PM
THEME
Neuroimaging and Other Biomarkers in VCI
SELECTED ORAL PRESENTATION
[P-181] Machine Learning Analysis of White Matter Hyperintensity Origin
PRESENTING AUTHOR
Mariana Bento (Canada)
Grand Hall
12:30 - 2:30 PM
LUNCH
Pre-Function Hall
12:30 - 2:30 PM
POSTER TOUR
Function Hall
2:30 - 3:30 PM
E-POSTER BLITZ SESSION
Grand Hall
3:30 - 4:00 PM
COFFEE BREAK
Pre-Function Hall
4:00 - 5:00 PM
DEBATE
Should silent stroke and high WMH burden be treated the same as symptomatic stroke?
MODERATOR
Eric Smith (Canada)
SPEAKERS
Christopher Chen (Singapore), Geert Jan Biessels (Netherlands), Sandra Black (Canada) and Vincent Mok (Hong Kong)
Grand Hall
5:00 - 7:00 PM
YOUNG INVESTIGATORS ORAL PRESENTATION
Grand Hall
5:00 - 6:15 PM
HK-CHINESE SYMPOSIUM / DEMENTIA PLATFORM
Cerebral Small Vessel Disease and Sleep Disorders
SPEAKER
Jian Hui Fu (China)
Risk Factors for Cerebrovascular Disease & Alzheimer's disease
SPEAKER
Hai Qing Song (China)
Cerebral Small Vessel Disease and Brain Network Study
SPEAKER
Qun Xu (China)
Treatment of Cognitive Impairment in Cerebral Small Vessel Disease
SPEAKER
Yu Hua Fan (China)
Harmonization of MRI Protocols in a Cerebral SVD Multi-Centre Study - The ICOS
SPEAKER
Bonnie Lam (Hong Kong) and Maxine Chen (Hong Kong)
Conference Hall 04, Convention Centre 2, Building 10W
7:00 - 8:00 PM
YOUNG INVESTIGATORS MIX N CHAT
Grand Hall
9:00 - 9:30 AM
THEME
Prevention and Treatment for VCI
PLENARY SESSION
Multi-Domain Interventions to Prevent Cognitive Impairment and Dementia
SPEAKER
Miia Kivipelto (Sweden)
Grand Hall
9:30 - 9:50 AM
THEME
Prevention and Treatment for VCI
SYMPOSIUM SESSION
Prevention and Treatment for VCI
SPEAKER
Deborah Gustafson (USA) and Bonnie Lam (Hong Kong)
Grand Hall
9:50 - 10:10 AM
THEME
Prevention and Treatment for VCI
SYMPOSIUM SESSION
Familial Alzheimer's disease in China
SPEAKER
Jianping Jia (China)
Grand Hall
10:10 - 10:20 AM
THEME
Prevention and Treatment for VCI
SELECTED ORAL PRESENTATION
[P-224] Atrial Fibrillation in Association with Dementia
PRESENTING AUTHOR
Ken Nagata (Japan)
Grand Hall
10:20 - 10:30 AM
THEME
Prevention and Treatment for VCI
SELECTED ORAL PRESENTATION
[P-118] Decreasing Prevalence and Incidence of Dementia Among Octogenarians is Most Accentuated in Women
PRESENTING AUTHOR
Hanna Wetterberg (Sweden)
Grand Hall
10:30 - 11:00 AM
COFFEE BREAK
Pre-Function Hall
11:00 - 11:30 AM
THEME
Vascular-Alzheimer’s Spectrum in Multiple Etiologies Dementias
PLENARY SESSION
An Update on the Importance of the Vascular Disease Pathway in the Alzheimer’s Clinical Syndrome.
SPEAKER
Julie Schneider (USA)
Grand Hall
11:30 - 11:50 AM
THEME
Vascular-Alzheimer’s Spectrum in Multiple Etiologies Dementias
SYMPOSIUM SESSION
Midlife Vascular Risk Factors and Alzheimer’s disease: Evidence from Epidemiology
SPEAKER
Rebecca Gottesman (USA)
Grand Hall
11:50 - 12:10 PM
THEME
Vascular-Alzheimer’s Spectrum in Multiple Etiologies Dementias
SYMPOSIUM SESSION
Statistically Modeling Neuropsychological Profiles in Vascular – Alzheimer’s Dementia and Mild Cognitive Impairment: Implications for Diagnosis and Clinical Trials
SPEAKER
David Libon (USA)
Grand Hall
12:10 - 12:20 PM
THEME
Vascular-Alzheimer’s Spectrum in Multiple Etiologies Dementias
SELECTED ORAL PRESENTATION
[P-19] Differentiating Between AD and VCI: Is the “Memory vs. Executive Function” Contrast Still Relevant?
PRESENTING AUTHOR
Olivier Godefroy (France)
Grand Hall
c
12:20 - 12:30 PM
THEME
Vascular-Alzheimer’s Spectrum in Multiple Etiologies Dementias
SELECTED ORAL PRESENTATION
[P-78] Complex Interplay Between Cerebral Gray and White Matter Integrity, Perfusion and Cognition in Alzheimer’s disease and Vascular Cognitive Impairment
PRESENTING AUTHOR
Chi-Wei Huang (Taiwan)
Grand Hall
12:30 - 2:30 PM
LUNCH
Pre-Function Hall
By bringing together international cohort studies of cognitive decline and dementia following stroke or transient ischaemic attacks (TIA) and other longitudinal studies of individuals at high risk of vascular cognitive disorders (VCD), the Stroke and Cognition consortium (STROKOG) aims to facilitate a better Understanding of the determinants and manifestations of vascular contributions to cognitive disorders and help improve the diagnosis and treatment of VCD. STROKOG has developed into a consortium of 30 studies from 18 countries in five continents, with a combined sample size of >16,000. The harmonisation project has been completed and the results will be presented at this special session by the STROKOG coordinator, Jessica Lo. The data show that the prevalence of post=stroke cognitive impairment is uniformly high across all cognitive domains. History of past stroke, and to a lesser degree, hypertension, AF, and smoking are associated w While some ethno-racial differences were seen, additional studies in non-White groups are required to further explore these differences in cognitive impairment.
12:30 - 1:30 PM
STROKOG SYMPOSIUM
Grand Hall
12:30 - 2:30 PM
POSTER TOUR
Function Hall
2:30 - 3:15 PM
E-POSTER BLITZ SESSION
Grand Hall
3:15 - 3:45 PM
COFFEE BREAK
Pre-Function Hall
3:15 - 3:45 PM
GENERAL ASSEMBLY
Grand Hall
3:45 - 4:45 PM
DEBATE
“Vessels OR tangles?” Do we really need diagnostic criteria for vascular and Alzheimer’s dementias?
MODERATOR
Raj Kalaria (United Kingdom)
SPEAKERS
Mark Bondi (USA), Velandai Srikanth (Australia), Perminder Sachdev (Australia) and Monique Breteler (Germany)
Grand Hall
4:45 - 5:15 PM
PLENARY SESSION
Vascular Dementia in the Developing World: A Growing Challenge
SPEAKER
Suvarna Alladi (India)
Grand Hall
5:15 - 6:15 PM
LATE-BREAKING CLINICAL TRIALS
[P-58] Methylphenidate Improves Executive Functioning in Patients with Vascular Cognitive Impairment – First Results of The STREAM-VCI Study
PRESENTING AUTHOR
Jolien Leijenaar (Netherlands)
[P-90] The CARMELINA®-Cognition Substudy: A Randomised, Clinical Trial on Cognitive Outcomes of Linagliptin Versus Placebo in Patients with Type2 Diabetes and High Cardio-Renal Risk
PRESENTING AUTHOR
Geert Jan Biessels (Netherlands)
[P-145] Intensive Versus Standard Blood Control on Cerebral Blood Flow in SVD: the PRESERVE (ASL) Trial
PRESENTING AUTHOR
Hugh Markus (United Kingdom)
[P-222] Ginkgo Biloba Extract EGb 761® Improves Cognition and General Condition in Patients who Suffered an Ischaemic Stroke – Results from a Pilot Study
PRESENTING AUTHOR
Yanxin Zhao (China)
Grand Hall
7:00 - 10:00 PM
VASCOG PARTY
House of Jasmine, Shop 401, Level 4, Ocean Centre, Harbour City, Tsim Sha Tsui
9:00 - 9:30 AM
THEME
Vascular Factors and Non-cognitive Symptoms
PLENARY SESSION
Vascular Diseases and Psychiatric Disorders. A Complex Relationship
SPEAKER
Ingmar Skoog (Sweden)
Grand Hall
9:30 - 9:50 AM
THEME
Vascular Factors and Non-cognitive Symptoms
SYMPOSIUM SESSION
“Walking, Thinking and Falling” – The Role of Vascular Ageing
SPEAKER
Velandai Srikanth (Australia)
Grand Hall
9:50 - 10:10 AM
THEME
Vascular Factors and Non-cognitive Symptoms
SYMPOSIUM SESSION
Delirium and Systemic Illness after TIA and Stroke: Associations and Potential Impact on Cognitive Decline
SPEAKER
Sarah Pendlebury (United Kingdom)
Grand Hall
10:10 - 10:20 AM
THEME
Vascular Factors and Non-cognitive Symptoms
SELECTED ORAL PRESENTATION
[P-63] Effects of Cognitive Dual-Tasking on Gait Impairment in Pure Small Vessel Disease
PRESENTING AUTHOR
Sofia Finsterwalder (Germany)
Grand Hall
10:20 - 10:30 AM
THEME
Vascular Factors and Non-cognitive Symptoms
SELECTED ORAL PRESENTATION
[P-82] Apathy is Associated With Disruption to Distinct Large-Scale White Matter Networks
PRESENTING AUTHOR
Jonathan Tay (United Kingdom)
Grand Hall
10:30 - 11:00 AM
COFFEE BREAK
Pre-Function Hall
11:00 - 11:30 AM
THEME
Technology in Detection and Assessment of VCI
PLENARY SESSION
Leveraging the Past and Enabling the future: Precision Monitoring for Vascular Brain Health
SPEAKER
Rhoda Au (USA)
Grand Hall
11:30 - 11:50 AM
THEME
Technology in Detection and Assessment of VCI
SYMPOSIUM SESSION
White Matter Disease in Healthy Older Adults: Relationships With Amyloid and Changes in Cognition
SPEAKER
Paul Maruff (Australia)
Grand Hall
11:50 - 12:10 PM
THEME
Technology in Detection and Assessment of VCI
SYMPOSIUM SESSION
Computational Intelligence in Neurology - From Research to Clinical Application
SPEAKER
Lin Shi (Hong Kong)
Grand Hall
12:10 - 12:20 PM
THEME
Technology in Detection and Assessment of VCI
SELECTED ORAL PRESENTATION
[P-103] Large-Scale Multivariate Lesion-Symptom Mapping Study on Strategic Infarct Location for Post-Stroke Cognitive Impairment – A Multicenter Proof-of-Concept Study from the Meta VCI Map Consortium
PRESENTING AUTHOR
Nick Weaver (Netherlands)
Grand Hall
c
12:20 - 12:30 PM
THEME
Technology in Detection and Assessment of VCI
SELECTED ORAL PRESENTATION
[P-217] The Brooklyn Cognitive Impairments in Health Disparities Pilot Study - Early Detection Using a Digital Cognitive Assessment Tool
PRESENTING AUTHOR
Deborah Gustafson (USA)
Grand Hall
12:30 - 1:00 PM
CLOSING CEREMONY
Grand Hall
