Dept. of Medicine & Therapeutics, The Chinese University of Hong Kong

Division of Gastroenterology and Hepatology

Head of Division: Prof. Francis KL Chan

Members:
Clinical: Prof. Joseph Sung (Professor) Prof. WK Leung (Professor) Prof. Henry LY Chan (Professor) Prof. Justin CY Wu (Associate Professor) Dr. YT Lee (Associate Consultant) Non-clinical: Dr. Terence CW Poon (Assistant Professor) Dr. Jun Yu (Research Assistant Professor) Fellow: Dr. Vincent WS Wong

Trainees:
Dr. Larry H Lai, Dr. Grace LH Wong, Dr Dorothy KL Chow

Nursing Officer:
Jessica Ching
Angel Chim

Research Assistant / Junior Research Assistant / Projector Coordinator:
Clinical:
Joyce Chan, Karen Yiu, Yawen Chan, Annie Lin, Darren Cheung, Carmen Yim, Envy Lee, Ken Yuen

Non-clinical:
Sunny Chu, Emma Lam, Catherine Chan, Angela Liang, Paul Cheung, Katherine Kwan, Jennifer Siu, Ada Tse, Wilson Chong, Wilson Wu, Amanda Lo, Eric Yip, Patrick Ho, Rosanna Leung

Research Associate / Research Technicians:
Eagle Chu, Christine Wong, Pete Tse, Yun Chan

Graduate Students:
Martin Chan, Victoria Cheng, Karen Shen, Fox Zhu, Julia Li, Richard Kam, Karen Yu, Irene Ang, Paul Cheung, Eric Ziea

Facilities:
Endoscopy Center
Cheng Suen Man Shook Foundation Center for Hepatitis Studies
Institute of Digestive Diseases

Research Interests
1.	H. pylori infection and Peptic Ulcer Disease
2.	Non-steroidal Anti-inflammatory Drugs and GI Toxicity
3.	Endoscopic Therapy of Gastrointestinal Bleeding
4.	Portal Hypertension and Complications
5.	Gastro-esophageal Reflux Disease

Selected Publications
1.	Sung, J. J.Y., S.C.S. Chung, K. L. Chan, C. W. Lai, C. Kassiandies, J.W.C. Leung, and A.K.C. Li. "Octreotide versus emergency sclerotherapy in the treatment of acute variceal haemorrhage." Lancet 1993; 342: 637-641.
2.	Sung, J. J., Y., S.C.S. Chung, T.K.W. Ling, M. Y. Yung, V.K.S. Leung, E.K.W. Ng, K.K. Li, A.F.B. Cheng, and A.K.C. Li. "Antibacterial Treatment of Gastric Ulcers Associated with Helicobacter pylori." N Engl J Med, 332(1995): 139-42.
3.	Sung, J. J., Y., S.C.S. Chung, M. Y. Yung, C. W. Lai, J.Y.W. Lau, Y. T. Lee, V.K.S. Leung, M.K.K. Li, A.K.C. Li. "Prospective Randomised Study of Effect of Octreotide on Rebleeding from Oesophageal Varices after Endoscopic Banding Ligation." Lancet, 346 (1995): 1666-69.
4.	Chan, F.K.L., J.J.Y. Sung, S.C.S. Chung, K. F. To, M. Y. Yung, V.K.S. Leung, Y. T. Lee, S.Y.C. Chan, E.K.M. Li, and J. Woo. "Randomized Trial of Eradication of Helicobacter Pylori before Non-steroidal Anti-inflammatory Drug Therapy to Prevent Peptic Ulcers." Lancet, 350 (1997): 975-79.
5.	Leung, W. K., J.J.Y. Sung, T.K.W. Ling, S.L.K. Siu, and A.F.B. Cheng. "Does the Use of Chopsticks for Eating Transmit Helicobacter Pylori." Lancet, 350 (1997): 31.
6.	Leung VKS, Sung JJY, Ahuja A, Tumala IE, Lee YT, Lau JYW, Chung SCS. "Large para-oesophageal varices on endosography predicts recurrent oesophageal varices and rebleeding." Gastroenterology 1997; 112: 1811-1816.
7.	Lau JYW, Sung JJY, Lam YH, Chan ACW, Ng EKW, Lee DWH, Chan FKL, Suen RCY, Chung SCS. "Endoscopic re-treatment versus surgery in patients rebleeding after initial endoscopic ulcer hemostasis: a prospective randomized controlled trial." N Engl J Med 1999; 340: 751-6.
8.	Lau JYW, Sung JJY, Lee KKC, Yung MY, Wong SKH, Wu JCY, Chan FKL, Ng EKW, You JHS, Lee CW, Chan ACW, Chung SCS. "A comparison of high-dose omeprazole infusion to placebo after endoscopic hemostasis to bleeding peptic ulcer." N Engl J Med 2000; 343: 310-316.
9.	Sung JJY, Lin SR, Ching JYL, Zhou LY, To KF, Wang RT, Leung WK, Ng EKW, Lau JYW, Yeung CK, Chao W, Chung SCS. "Atrophy and intestinal metaplasia at one year after cure of H. pylori infection: a prospective, randomized study." Gastroenterol 2000; 119: 7-14.
10.	Chan FKL, Chung SCS, Suen BY, Lee YT, Leung WK, Leung VKS, Wu JCY, Lau JYW, Hui Y, Lai MS, Chan HLY, Sung JJY. "A randomised comparison of Helicobacter pylori eradication and omeprazole for the prevention of recurrent upper gastrointestinal bleeding in chronic users of low-dose aspirin and non-aspirin non-steroidal anti-inflammatory drugs." N Engl J Med 2001; 344:967-973.
11.	Chan FK, Hung LC, Suen BY, Wu JC, Lee KC, Leung VK, Hui AJ, To KF, Leung WK, Wong VW, Chung SC, Sung JJ. Celecoxib versus diclofenac and omeprazole in reducing the risk of recurrent ulcer bleeding in patients with arthritis. N Engl J Med. 2002;347:2104-10.
12.	Chan FK, To KF, Wu JC, Yung MY, Leung WK, Kwok T, Hui Y, Chan HL, Chan CS, Hui E, Woo J, Sung JJ. Eradication of Helicobacter pylori and risk of peptic ulcers in patients starting long-term treatment with non-steroidal anti-inflammatory drugs: a randomised trial. Lancet. 2002;359:9-13 .
13.	Chan FK, Leung WK. Peptic-ulcer disease. Lancet. 2002;360:933-41.
14.	Sung JJ, Chan FK, Leung WK, Wu JC, Lau JY, Ching J, To KF, Lee YT, Luk YW, Kung NN, Kwok SP, Li MK, Chung SC. Screening for colorectal cancer in Chinese: comparison of fecal occult blood test, flexible sigmoidoscopy, and colonoscopy. Gastroenterology. 2003;124:608-14.
15.	Sung JJ, Chan FK, Lau JY, Yung MY, Leung WK, Wu JC, Ng EK, Chung SC. The effect of endoscopic therapy in patients receiving omeprazole for bleeding ulcers with nonbleeding visible vessels or adherent clots: a randomized comparison. Ann Intern Med. 2003;139:237-43 .
16.	Chan FK, Ching JY, Hung LC, Wong VW, Leung VK, Kung NN, Hui AJ, Wu JC, Leung WK, Lee VW, Lee KK, Lee YT, Lau JY, To KF, Chan HL, Chung SC, Sung JJ. Clopidogrel versus aspirin and esomeprazole to prevent recurrent ulcer bleeding. N Engl J Med. 2005;352:238-44.
17.	Chan FK, Hung LC, Suen BY, Wong VW, Hui AJ, Wu JC, Leung WK, Lee YT, To KF, Chung SC, Sung JJ. Celecoxib versus diclofenac plus omeprazole in high-risk arthritis patients: results of a randomized double-blind trial. Gastroenterology. 2004;127:1038-43.
18.	Hung LC, Ching JY, Sung JJ, To KF, Hui AJ, Wong VW, Leong RW, Chan HL, Wu JC, Leung WK, Lee YT, Chung SC, Chan FK. Long-term outcome of Helicobacter pylori-negative idiopathic bleeding ulcers: a prospective cohort study. Gastroenterology. 2005;128:1845-50 .
19.	Sung JJY, Wong ML, Bowden S, Liew CT, Hui AY, Wong VWS, Leung NWY, Locarnini S, Chan HLY. Intrahepatic hepatitis B virus covalently closed circular DNA can be a predictor of sustained response to therapy. Gastroenterology 2005;128:1890-97.
20.	Chan HLY, Leung NWY, Hui AY, Wong VWS, Liew CT, Chim AML, Chan FKL, Hung LCT, Lee YT, Tam JSL, Lam CWK, Sung JJY. Peginterferon alfa-2b and lamivudine versus lamivudine alone for chronic hepatitis B. A randomized controlled trial. Ann Intern Med 2005;142:240-50.